| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Non-Customized |
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| Introduction |
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Fludarabine, with the chemical name 9H-Purin-6-amine, F-Ara-A
Fludarabinum, monosodium salt, and CAS number 21679-14-1, is a synthetic purine nucleoside analog that has gained prominence as an antineoplastic and immunosuppressive agent. It is a vital component in the field of oncology and hematology, used primarily for the treatment of various hematologic malignancies, particularly chronic lymphocytic leukemia (CLL). Fludarabine exerts its therapeutic effects by interfering with DNA synthesis and repair processes, disrupting cell division, and inducing apoptosis in rapidly dividing cells. This compound's unique mechanism of action and clinical significance make it an essential tool in the arsenal of treatments for certain hematological disorders.
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| Function |
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1. Purine Nucleoside Analog: Fludarabine is a synthetic analog of the purine nucleoside adenosine. This structural resemblance allows it to be incorporated into DNA and RNA during replication and transcription, disrupting normal cellular processes.
2. Selective Action: Fludarabine is more readily taken up by malignant cells, particularly lymphocytes, compared to normal cells. This selective uptake contributes to its effectiveness against certain hematologic cancers like chronic lymphocytic leukemia (CLL).
3. Immunosuppressive Properties: Besides its antineoplastic effects, fludarabine also exhibits immunosuppressive properties. This makes it valuable for conditions like CLL, where excessive immune activity contributes to disease progression.
4. Inhibition of DNA Repair: Fludarabine interferes with DNA repair enzymes, leading to accumulation of DNA strand breaks and impairing DNA synthesis. This mechanism contributes to its cytotoxic effects on rapidly dividing cancer cells.
5. Resistance Minimization: Fludarabine's structural modification from the naturally occurring nucleoside reduces susceptibility to degradation by adenosine deaminase, an enzyme that can impact the effectiveness of other nucleoside analogs.
6. Route of Administration: Fludarabine is typically administered intravenously, allowing for controlled dosing and efficient delivery to target cells.
7. Combination Therapy: Fludarabine is often used in combination with other chemotherapeutic agents or monoclonal antibodies to enhance treatment efficacy in hematologic malignancies.
8. Dose Adjustment: Fludarabine dosages may need to be adjusted based on factors such as renal function and patient tolerance to minimize potential side effects.
9. Clinical Versatility: Beyond CLL, fludarabine has demonstrated effectiveness in treating other hematologic disorders like acute myeloid leukemia and non-Hodgkin lymphomas.
10. Adverse Effects: Common side effects of fludarabine therapy include myelosuppression, immunosuppression, and potential risk of opportunistic infections. |
| Application |
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1. Chronic Lymphocytic Leukemia (CLL)
Fludarabine is widely used as a first-line or second-line treatment for CLL, a type of leukemia characterized by the abnormal accumulation of mature lymphocytes. It has shown significant response rates and can help manage the disease, especially in patients who have not responded well to other treatments.
2. Acute Myeloid Leukemia (AML)
Fludarabine, often in combination with other chemotherapy agents, is used to treat AML, a rapidly progressing cancer that affects myeloid cells in the bone marrow and blood.
3. Non-Hodgkin Lymphomas (NHL)
Fludarabine is incorporated into chemotherapy regimens for certain types of NHL, including indolent and mantle cell lymphomas, to enhance treatment outcomes.
4. Hairy Cell Leukemia
Fludarabine has demonstrated effectiveness in treating hairy cell leukemia, a rare form of chronic leukemia affecting B cells.
5. Stem Cell Transplantation
Fludarabine is often used as part of conditioning regimens before allogeneic hematopoietic stem cell transplantation (HSCT) in patients with hematologic malignancies. The aim is to suppress the patient's immune system and create a favorable environment for successful transplantation.
6. Investigational Therapies
Fludarabine is sometimes explored in clinical trials for other hematologic disorders and malignancies, as well as in combination therapies with newer targeted agents.
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| Oleanolic acid | Naringenin | Bovine colostrum powder | BHB-Ca/Na/Mg | Pterostilbene |
| Food Additives - Sweeteners | ||||
| Stevioside | Erythritol | Sucralose | Trehalose | Polydextrose |
| Neotame | Stachyose | Allulose(Psicose) | Aspartame | Acesulfame |
| D-Ribose | D-Mannitol | D-xylose | D-arabinose | L-arabinose |
| Isomalt | Maltitol | Lactose | Sorbitol | Xylitol |
| Momordicaglycosides | Crystalline Fructose | Xylo-oligosaccharide( XOS) | Fructo-oligosaccharide(FOS) | Isomaltulose(Palatinose) |
| Vitamin A Series | Vitamin A Acetate Powder | Vitamin E Series | Mixed tocopherol Oil |
| Vitamin A Palmitate Oil | Mixed tocopherol powder | ||
| Vitamin D Series | Vitamin AD3 | D-gamma tocopherol Oil | |
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| Vitamin D3 Oil | D-alpha Tocopherol Oil | ||
| Vitamin C (Ascorbic Acid) | Vitamin C(Ascorbic Acid) | D-alpha Tocopheryl Acetate Oil | |
| Calcium Ascorbate | D-alpha Tocopheryl Acetate Powder | ||
| Sodium Ascorbate | D-alpha Tocopheryl Succinate Powder | ||
| Beta Carotene | Beta Carotene Powder | Vitamin K2 Series | MK-4 Powder/Oil |
| Beta Carotene Oil | MK-7 Powder/Oil | ||
| Vitamin B Series | B1,B2,B3,B5,B6,B7.B9.B12 | MK-9 Powder/Oil | |
| Lipoic acid | Alpha lipoic acid | Vitamin K1 | Vitamin K1 |
| R-(+) -lipoic acid |
| L-Cysteine hydrochloride monohydrate | L-Cysteine hydrochloride anhydrous | L-Cysteine | N-Acetyl-L-Cysteine |
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| L-Glutamic acid | L-Threonine | L-Arginine HCI | L-Leucine |
| L-Tyrosine | L-Cystine | L-Alanine | DL-Alanine |
| DL-Methionine | L-Methionine | L-Arginine base | L-isoleucine |
| L-Valine | L-Phenylalanine | L-Glutamine | L-Histidine |
| L-Histidine monohydrochloride | L-Lysine | L-Serine | L-Citrulline |
| L-Aspartic acid | L-Proline | L-Asparagine | L-Ornithine monohydrochloride |
| L-Hydrotyproline | B-Alanine | Taurine | Disodium succinate |
| Q: What types of cosmetic raw materials do you supply? |
| We supply a wide range of cosmetic raw materials, including but not limited to whitening agents, moisturizing agents, antioxidation, emollients, surfactants, preservatives, pigments, and active ingredients to meet diverse formulation needs. |
| Q: How can I place an order for cosmetic ingredients? |
| To place an order, simply browse our product catalog, select the desired items, and follow the online checkout process. If you have specific requirements or need assistance, our customer service team is ready to help. |
| Q: What is the minimum order quantity for your cosmetic raw materials? |
| The minimum order quantity varies by product. You can find this information on the product pages or contact our sales team for specific details. Usually MOQ is from 1kg. |
| Q: Can I request a sample of a specific cosmetic ingredient before placing a bulk order? |
| Yes, we offer sample sizes for most of our products. You can request samples through our website, and our team will assist you in choosing the right products for your needs. |
| Q: What quality standards do your cosmetic raw materials adhere to? |
| Our cosmetic raw materials adhere to industry-standard quality and safety regulations. We ensure compliance with relevant standards and provide documentation, such as Certificates of Analysis, upon request. |
| Q: What payment methods do you accept for cosmetic ingredient purchases? |
| We accept various payment methods, including credit cards, bank transfers, and other secure online payment options. Details are available during the checkout process. |
| Q: How do you ensure the timely delivery of cosmetic raw materials? |
| We work with reliable shipping partners to ensure timely and secure delivery of your orders. You can track your shipment through tracking website and our customer service team is available to assist with any delivery-related inquiries. |
| Q: Do you provide technical support or documentation for the proper usage of your cosmetic raw materials? |
| Absolutely. We offer technical support and provide comprehensive documentation, including usage guidelines and formulation recommendations. Our team is available to address any technical inquiries you may have. |
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