Manufacturer Direct Supply High Purity Alzheimer′ S Disease Anti-Aging Anti-Inflammatory Raw Material CAS 1353224-53-9 Cms-121 Powder

• CAS No.: 1353224-53-9
• Formula: C20h19no3
• EINECS: -
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Technical
• Model NO.: CMS-121
• Colour: White
• Product Name: Cms-121
• Documents: COA/MSDS/TDS
• CAS No: 1353224-53-9
• Application: Nutritional Supplements
• Transport Package: 1kg/Bag; 25kg/Drum
• Specification: 98%
• Trademark: Greenway
• Origin: China

Product Description

Introduction

CMS121, a synthesized variant of fisetin, a chemical found in fruits and vegetables, improved memory, and slows neurodegeneration in mouse models of Alzheimer's disease.

Function

CMS121 is a substituted quin oline that has neuroprotective, anti-inflammatory, antioxidative, and renoprotective activities. It maintains glutathione (GSH) levels in HT22 mouse hippocampal cells in vitro in the presence of glutamate, induces differentiation of PC12 cells, prevents LPS-induced N9 microglial activation by 82% in N9 microglia, and scavenges free radicals in a Trolox equivalent activity concentration (TEAC) assay. CMS121 protects against ischemia and oxytosis in phenotypic screens in HT22 cells in vitro with EC50 values of 7 and 200 nM for preventing iodoacetic acid- or glutamate-induced cell death, respectively. It is also renoprotective, decreasing kidney weight loss and decreasing the expression of TNF-α, caspase-1, and inducible nit ric oxi de synthase (iNOS) in a SAMP8 mouse model of chronic kidney disease associated with rapid aging when administered at a dose of 10 mg/kg per day starting at nine months of age.

Application

CMS-121 (CMS121) is a novel and potent fisetin-based derivative with anti-aging, neuroprotective, anti-inflammatory, antioxidative, and renoprotective activities.

Curcumin	Tetrahydrocurcumin	Phycocyanin	PQQ	NMN
NR-CL	NAD	Citicoline	Citicoline Sodium	Genistein
Oxidized Glutathione	L-Glutathione Reduced	Alpha Lipoic Acid	R(+)-alpha-lipoic acid	DL-lipoic acid
L-Carnosine	Beta-Glucan	Phosphatidylserine	EGCG	Theanine
Chitosan	Chitosan oligosaccharide	Berberine hydrochloride	S-Acetyl L-Glutathione	Zeaxanthin
Kaempferol	Urolithin A	Alpha GPC 99% 50%	Palmitoylethanolamide/PEA	Urolithin B
Lutein	Alpha Ketoglutarate	Creatine monohydrate	Fadogia Agrestis	Boswellic acid
Coenzyme Q10	Astaxanthin powder/oil	Chondroitin sulfate	Magnesium threonate	Collagen
Phenibut	BCAA	Ajuga Turkestanica Extract Turkesterone	Sulforaphane	Boric acid flakes
Hyaluronic acid	L-carnitine	Zinc Picolinate	Ghana Seed Extract 5-HTP	Melatonin
Resveratrol	GABA aminobutyric acid	Tauroursodeoxycholic Acid Tudca	ATP adenosine triphosphate	Artemisinin
Oleanolic acid	Naringenin	Bovine colostrum powder	BHB-Ca/Na/Mg	Pterostilbene

Vitamin A Series	Vitamin A Acetate Powder	Vitamin E Series	Mixed tocopherol Oil
	Vitamin A Palmitate Oil		Mixed tocopherol powder
Vitamin D Series	Vitamin AD3		D-gamma tocopherol Oil
	Vitamin D3 Powder		D-delta tocopherol Oil
	Vitamin D3 Oil		D-alpha Tocopherol Oil
Vitamin C (Ascorbic Acid)	Vitamin C(Ascorbic Acid)		D-alpha Tocopheryl Acetate Oil
	Calcium Ascorbate		D-alpha Tocopheryl Acetate Powder
	Sodium Ascorbate		D-alpha Tocopheryl Succinate Powder
Beta Carotene	Beta Carotene Powder	Vitamin K2 Series	MK-4 Powder/Oil
	Beta Carotene Oil		MK-7 Powder/Oil
Vitamin B Series	B1,B2,B3,B5,B6,B7.B9.B12		MK-9 Powder/Oil
Lipoic acid	Alpha lipoic acid	Vitamin K1	Vitamin K1
	R-(+) -lipoic acid

L-Cysteine hydrochloride monohydrate	L-Cysteine hydrochloride anhydrous	L-Cysteine	N-Acetyl-L-Cysteine
S-Carboxymethyl-L-Cysteine	L-Tryptophan	Glycine	L-Lysine monohydrochloride
L-Glutamic acid	L-Threonine	L-Arginine HCI	L-Leucine
L-Tyrosine	L-Cystine	L-Alanine	DL-Alanine
DL-Methionine	L-Methionine	L-Arginine base	L-isoleucine
L-Valine	L-Phenylalanine	L-Glutamine	L-Histidine
L-Histidine monohydrochloride	L-Lysine	L-Serine	L-Citrulline
L-Aspartic acid	L-Proline	L-Asparagine	L-Ornithine monohydrochloride
L-Hydrotyproline	B-Alanine	Taurine	Disodium succinate

 

Private Label OEM Capsules with Jar

1. Customized formulas and packaging.
2. High-quality labels and materials.
3. Various capsule capacities available.
4. Stringent printing and quality control.
5. Secure packaging and shipping.

Private Label Bag with powder

1. Customized sizel options for packaging bags.
2. Unique packaging design with customized printing.
3. Customized powder formula available.
4. Strict printing and quality control measures.
5. Secure packaging and transportation.
 

Q: What types of cosmetic raw materials do you supply?

We supply a wide range of cosmetic raw materials, including but not limited to whitening agents, moisturizing agents, antioxidation, emollients, surfactants, preservatives, pigments, and active ingredients to meet diverse formulation needs.

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Our cosmetic raw materials adhere to industry-standard quality and safety regulations. We ensure compliance with relevant standards and provide documentation, such as Certificates of Analysis, upon request.

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Absolutely. We offer technical support and provide comprehensive documentation, including usage guidelines and formulation recommendations. Our team is available to address any technical inquiries you may have.